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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Maslinic acid
PubChem CID 73659
Molecular Weight 472.7g/mol
Synonyms

(2alpha, 3beta)-2,3-dihydroxy-olean-12-en-28-oic acid, (2alpha, 3beta)-2,3-dihydroxyolean-12-en-28-oic acid, (2beta, 3alpha)-2,3-dihydroxy-olean-12-en-28-oic acid, (2beta, 3alpha)-2,3-dihydroxyolean-12-en-28-oic acid, 2-hydroxyoleanolic acid, 2alpha-hydroxyoleanolic acid, bredemolic acid, crataegolic acid, crategolic acid, maslic acid, maslinic acid, olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha, 3beta)-
Formula C₃₀H₄₈O₄
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1)C)C(=O)O)C
InChI 1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1
InChIKey MDZKJHQSJHYOHJ-LLICELPBSA-N
CAS Number 4373-41-5
ChEMBL ID CHEMBL201515
ChEBI ID CHEBI:66682
KEGG ID C16939
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Pogostemon cablin Warm
Chineses Pinyin HuoXiang
Use Part Aerial Parts
Habitat GuangDong, HaiNan
Flavor Pungent
Meridian Tropism Spleen, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Lamiaceae
　　　　　-->Genus: Pogostemon
　　　　　　-->Species: Pogostemon cablin
(2) Prunella vulgaris Cold
Chineses Pinyin XiaKuCao
Use Part Spike
Habitat China
Flavor Pungent, Bitter
Meridian Tropism Liver, Gallbladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Lamiaceae
　　　　　-->Genus: Prunella
　　　　　　-->Species: Prunella vulgaris
(3) Swertia mileensis Cold
Chineses Pinyin QingYeDan
Use Part Whole Herb
Habitat YunNan, SiChuan, GuiZhou, GuangDong, GuangXi, HuNan, FuJian
Flavor Bitter, Sweet
Meridian Tropism Liver, Gallbladder, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Gentianaceae
　　　　　-->Genus: Swertia
　　　　　　-->Species: Swertia mileensis
(4) Ephedra sinica Even
Chineses Pinyin MaHuangGen
Use Part Root
Habitat HeBei, ShanXi, NeiMengGu, GanSu, SiChuan
Flavor Sweet, Astringent
Meridian Tropism Heart, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Ephedrales
　　　　-->Family: Ephedraceae
　　　　　-->Genus: Ephedra
　　　　　　-->Species: Ephedra sinica
(5) ActinidiachinensisPlanch Cold
Chineses Pinyin MiHouTao
Use Part Fruit
Habitat HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, Shaanxi, SiChuan, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, GuiZhou, YunNan
Flavor Sour, Sweet
Meridian Tropism Stomach, Liver
(6) Ligustrum lucidum Cool
Chineses Pinyin NvZhenZi
Use Part Fruit
Habitat ZheJiang, JiangSu, HuNan, FuJian, GuangXi, JiangXi, SiChuan
Flavor Sweet, Bitter
Meridian Tropism Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Oleaceae
　　　　　-->Genus: Ligustrum
　　　　　　-->Species: Ligustrum lucidum
(7) Rubus chingii Hu Warm
Chineses Pinyin FuPenZi
Use Part Aggregate Fruit
Habitat AnHui, JiangSu, ZheJiang
Flavor Sweet, Sour
Meridian Tropism Liver, Kidney, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Rubus
　　　　　　-->Species: Rubus chingii
(8) Eriobotrya japonica Cold
Chineses Pinyin PiPaYe
Use Part Leaf
Habitat GuangDong, JiangSu, ZheJiang, FuJian, HuBei
Flavor Bitter
Meridian Tropism Lung, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Eriobotrya
　　　　　　-->Species: Eriobotrya japonica
(9) Crataegus pinnatifida Even
Chineses Pinyin ShanZhaYe
Use Part Leaf
Habitat ShanDong, HeNan, HeBei, LiaoNing
Flavor Sour
Meridian Tropism Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Crataegus
　　　　　　-->Species: Crataegus pinnatifida
(10) Potentilla chinensis Cold
Chineses Pinyin WeiLingCai
Use Part Whole Herb With Root
Habitat HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, ChongQing, Shaanxi, GanSu, ShanDong, JiangSu, AnHui, ZheJiang, JiangXi, TaiWan, XiZang
Flavor Bitter
Meridian Tropism Liver, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Potentilla
　　　　　　-->Species: Potentilla chinensis
(11) Ligusticum chuam Warm
Chineses Pinyin ChuanXiong
Use Part Rhizome
Habitat SiChuan
Flavor Pungent
Meridian Tropism Liver, Gallbladder, Pericardium
(12) Cornus officinalis Warm
Chineses Pinyin ShanZhuYu
Use Part Fruit
Habitat HeNan, ZheJiang
Flavor Sour, Astringent
Meridian Tropism Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Cornales
　　　　-->Family: Cornaceae
　　　　　-->Genus: Cornus
　　　　　　-->Species: Cornus officinalis
(13) Punica granatum Warm
Chineses Pinyin ShiLiuPi
Use Part Pericarp
Habitat China
Flavor Sour, Astringent
Meridian Tropism Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Myrtales
　　　　-->Family: Lythraceae
　　　　　-->Genus: Punica
　　　　　　-->Species: Punica granatum
(14) Ziziphus jujuba Warm
Chineses Pinyin DaZao
Use Part Ripe Fruit
Habitat HeNan, HeBei, ShanDong
Flavor Sweet
Meridian Tropism Spleen, Stomach, Heart
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rhamnaceae
　　　　　-->Genus: Ziziphus
　　　　　　-->Species: Ziziphus jujuba
(15) Boehmeria nivea Cold
Chineses Pinyin ZhuMaGen
Use Part Root, Rhizome
Habitat ZheJiang, JiangSu, AnHui
Flavor Sweet
Meridian Tropism Liver, Heart, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Urticaceae
　　　　　-->Genus: Boehmeria
　　　　　　-->Species: Boehmeria nivea
(16) Rehmannia glutinosa Cold
Chineses Pinyin GanDiHuang
Use Part Dried Root
Habitat HeNan, ZheJiang, JiangSu, AnHui, ShanDong, HeBei, LiaoNing, ShanXi, Shaanxi, NeiMengGu, HuNan, HuBei, SiChuan
Flavor Sweet, Bitter
Meridian Tropism Heart, Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Orobanchaceae
　　　　　-->Genus: Rehmannia
　　　　　　-->Species: Rehmannia glutinosa
(17) Terminalia chebula Warm
Chineses Pinyin HeZiYe
Use Part Leaf
Habitat YunNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, GuangDong, GuangXi
Flavor Bitter
Meridian Tropism Lung, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Myrtales
　　　　-->Family: Combretaceae
　　　　　-->Genus: Terminalia
　　　　　　-->Species: Terminalia chebula
(18) Rosa laevigata Even
Chineses Pinyin JinYingYe
Use Part Leaf
Habitat Shaanxi, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, TaiWan, HeNan, HuBei, HuNan, GuangDong, HaiNan, GuangXi, SiChuan, GuiZhou, YunNan
Flavor Bitter
Meridian Tropism Lung, Heart
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Rosa
　　　　　　-->Species: Rosa laevigata
(19) Paulownia tomentosa Unknown
Chineses Pinyin MaoPaoTong
Use Part Bark
Habitat LiaoNing, HeBei, HeNan, ShanDong, JiangSu, AnHui, HuBei, JiangXi
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Paulowniaceae
　　　　　-->Genus: Paulownia
　　　　　　-->Species: Paulownia tomentosa
(20) Myricarubra Warm
Chineses Pinyin YangMei
Use Part Fruit
Habitat JiangSu, ZheJiang, JiangXi, FuJian, TaiWan, HuNan, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan
Flavor Bitter
Meridian Tropism Lung, Stomach
(21) Crataegus pinnatifida Warm
Chineses Pinyin ShanZha
Use Part Fruit
Habitat ShanDong, HeNan, HeBei, LiaoNing
Flavor Sour; Sweet
Meridian Tropism Spleen; Stomach; Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Tracheophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Crataegus
　　　　　　-->Species: Crataegus pinnatifida
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 222
Ref_1
Pair Name Maslinic acid, Gemcitabine
Partner Name Gemcitabine
Disease Info [ICD-11: 2C94] Bladder cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression CCND1 hsa595
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
Down-regulation Activity NFKB1 hsa4790
In Vitro Model EH-GB1 Gallbladder carcinoma Homo sapiens (Human) CVCL_IU73
EH-GB2 Gallbladder carcinoma Homo sapiens (Human) CVCL_6899
GBC-SD Gallbladder carcinoma Homo sapiens (Human) CVCL_6903
In Vivo Model EH-GB2 tumor cells were subcutaneously injected into the mice (2×10⁶ cells/mouse).
Result The results suggest that MA potentiates the antitumor effects of GEM in human GBC cell lines by suppressing the activation of NF-κB and its dowstream gene products, which are involved in survival signaling.
04. Reference
No. Title Href
1 Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-κB-mediated survival signaling pathways in human gallbladder cancer cells. Oncol Rep. 2015 Apr;33(4):1683-90. doi: 10.3892/or.2015.3755. Click
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